Maria Fernanda Espinosa, Susana Malcorra and Jody Williams have decades of combined experience in enriching the global debates on how to enhance the effectiveness of our mechanisms of international cooperation and innovate in ways that contribute to buttress our tottering global order. In this wide-ranging interview, before an audience of some 600 students and faculty at one of Spain´s leading universities, they discuss the aftermath of COVID, the meaning of human security, the climate emergency, our unraveling nuclear order, leadership in the 21^st century, the future of the United Nations and more.